Samaneh Sabouri; Mohsen Foroughipour; Elaheh Emadi; Daryoush Hamidi Alamdari
Abstract
Introduction: In multiple sclerosis (MS), oxidative stress (OS) performs a vital role in the neurodegeneration process. Cholesterol and lipids in the myelin sheath supplied by low-density lipoprotein (LDL) are also vital for nerve cells. In OS, lipid peroxidation occurs in LDL. Objective: To investigate ...
Read More
Introduction: In multiple sclerosis (MS), oxidative stress (OS) performs a vital role in the neurodegeneration process. Cholesterol and lipids in the myelin sheath supplied by low-density lipoprotein (LDL) are also vital for nerve cells. In OS, lipid peroxidation occurs in LDL. Objective: To investigate the OS biomarker such as prooxidant-antioxidant balance (PAB), malondialdehyde (MDA) and their correlation with LDL and oxidized LDL (Oxi-LDL) in patients with relapsing-remitting MS.Methods: Blood samples from 18 patients with relapsing-remitting MS and 18 healthy subjects were collected to measure the OS biomarkers.Results: In the patients' group in comparison to the control group: PAB, white blood cells (WBC), and neutrophils significantly increased (P<0.05), but there was no difference between the relapsing and remitting phase; MDA significantly increased in the relapsing phase (P=0.013), but marginally significant in remitting (P=0.068). There was no significant difference in LDL and Oxi-LDL between the two groups. Only the lymphocytes were different between the relapse and remission phases. Conclusion: The importance of OS in the process of MS disease was confirmed and a PAB assay can be used for the determination of OS levels.
Vahideh Banazadeh; Ali Jangjoo; Andisheh Norouzian Ostad; Golnaz Ranjbar; Mahdi Jabbari Noghabi; Daryoush Hamidi Alamdari; Majid Ghayour Mobarhan; Reyhaneh Faridnia; Mohsen Nematy
Abstract
Introduction:Gastric bypass surgery is an intervention used to treat class III obesity and its complications. Evidence is scarce regarding its benefits among the Iranian population, especially its role in resolving obesity-related complaints and comorbidities. The present study aimed to investigate the ...
Read More
Introduction:Gastric bypass surgery is an intervention used to treat class III obesity and its complications. Evidence is scarce regarding its benefits among the Iranian population, especially its role in resolving obesity-related complaints and comorbidities. The present study aimed to investigate the impact of gastric bypass surgery on the improvement of obesity-related complaints and comorbidities in morbid obesity. Methods:This study was conducted on 35 morbidly obese patients who volunteered to undergo gastric bypass surgery. Anthropometric data, comorbidity status, and dietary habits were collected at baseline and six months postoperatively. Data analysis was performed in SPSS version 16.0. Results: The majority of the patients were female (80%). A significant difference was observed in the frequency distribution of normal dietary habits (five regular meals per day) before and after surgery (P = 0.01). In comparison, the distribution was not significant for snacking and three large meals per day (P > 0.05). All complaints of eating disorders according to self-reports (e.g., overeating and night eating syndrome) significantly improved (P < 0.05 ). Moreover, the dose of the medications prescribed for the comorbidities associated with obesity reduced significantly (P = 0.001). The frequency of several obesity-related complaints (e.g., knee pain, hirsutism, acanthosis nigricans, and sleep apnea) also decreased significantly (P < 0.05). However, no significant improvement was observed in hair loss, brittle nails, and menstrual dysfunction (P > 0.05). Conclusion: Accordingly, gastric bypass surgery could improve obesity-related complaints six months postoperatively. Also, according to the patients’ self -declaration, patients’ adherence to “normal eating habits” increased during this period, and their eating disorders like night eating syndrome (NES) and overeating behaviors decreased compared to before the surgery.