Mina Nosrati; Neda Shakour; Toktam Sahranavard; Fatemeh Sadabadi; Sara Saffar Soflaei; Hamideh Ghazizadeh; Maryam Mohammadi Bajgiran; Mohamad Reza Latifi; Mohammad Amin Mansouri; Mahmoud Ebrahimi; Mohsen Mouhebati; Seyed Hassan Mirshafee; Masoumeh Haghighi; Reza Assaran Darban; Ensieh Akbarpour; Gordon A. Ferns; Habibollah Esmaily; Majid Ghayour-Mobarhan
Abstract
Introduction: Diabetes (DM) is a type of metabolic disorder that its types are generated by collectingof genetic and environmental risk agents. Here, the association between HSPB1 polymorphism as a genetic risk factor and DM was investigated.
Methods: Total 690 participants from MASHAD cohort study ...
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Introduction: Diabetes (DM) is a type of metabolic disorder that its types are generated by collectingof genetic and environmental risk agents. Here, the association between HSPB1 polymorphism as a genetic risk factor and DM was investigated.
Methods: Total 690 participants from MASHAD cohort study population were recruited into the study.Anti-HSP27-level was assessed followed by genotyping using Taqman®-probes-based assay. Anthropometric, demographic and hematological/biochemical characteristics were evaluated. Kaplan-Meier curves were utilized, while logistic regression models were used to assess the association of the genetic variant with clinical characteristics of population.
Results: Finds was shown there are meaningful differences among groups of age, height, waist circumference, systolic blood pressure, FBG,TG, HDL-C, and hs-CRP, and was no big -significant difference between theexists in different HSP27 SNP in the two studied groups (with and without DM), also was no remarkable relation between genetic forms of HSPB1and T2DM. This investigation was the first research that analyzed the relationship between the genetic type of the HSPB1 gene (rs2868371) and Type 2 diabetes (DM2). In our population, the CC genotype (68.1%) had a higher prevalence versus GC (26.6%) and GG (5.3%) genotypes and the data shown that no genetic difference of HSPB1 gene polymorphism (rs2868371) was related with DM2.
Conclusion: HSPB1 polymorphism, rs2868371, was not associated with type 2 diabetes mellitus.
Sepideh Babaniamansour; Nooshin Najari; Ehsan Aliniagerdroudbari; Amirmohammad Babaniamansour; Saeed Pezeshki
Abstract
Introduction:One of the most common diabetes complications is diabetic foot ulcer (DFU). Besides conventional treatments, hyperbaric oxygen therapy (HBOT) is known as an adjunctive therapy for DFU. This study aimed to investigate the efficacy of HBOT and possible risk factors. Methods:This study was ...
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Introduction:One of the most common diabetes complications is diabetic foot ulcer (DFU). Besides conventional treatments, hyperbaric oxygen therapy (HBOT) is known as an adjunctive therapy for DFU. This study aimed to investigate the efficacy of HBOT and possible risk factors. Methods:This study was conducted in two hyperbaric clinics of Bahar and Khatam, respectively in Isfahan and Tehran, Iran, between September 2016 and September 2017. Eligible participants underwent 100% oxygen at 2 to 2.5 atmosphere absolute for 90 to 120 minutes daily (five days per week). Data were analyzed with SPSS version 24.0. Results: The recovery rate was 69% in 58 enrolled patients and had a significant direct association with good glycemic control status, before (p <0.01) and during HBOT (P < 0.01), and low-grade ulcers (P= 0.04). The mean number of HBOT sessions of the cured patients (21.5±17.1) was significantly higher than that of the not cured patients (11.3 ± 7.9) (P= 0.02). However, the recovery rate had no significant association with the type of ulcer (P= 0.1). Conclusion: HBOT had good efficacy and a high recovery rate in DFU treatment. Given the fact that good glycemic control status reduces the incidence of ulcers, this study showed that it increased the DFU recovery rate under HBOT.
Davood Oliaee; Hamid Reza Niazkar; Abbasali Abbasnezhad; Mohammad Ghorbani; Parisa Sadat Alavi Shahri; Saeide Saghaee Shahri; Kasra Ghanaiyan
Abstract
Introduction: Diabetes mellitus (DM) is a metabolic disorder with a high prevalence, which affects approximately 25% of the world’s population. This systematic review aimed to assess the Iranian research regarding the effects of medicinal plants on pancreatic beta cells in diabetes.Methods: This ...
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Introduction: Diabetes mellitus (DM) is a metabolic disorder with a high prevalence, which affects approximately 25% of the world’s population. This systematic review aimed to assess the Iranian research regarding the effects of medicinal plants on pancreatic beta cells in diabetes.Methods: This systematic review was conducted via searching in databases such as Medline, PubMed, Google Scholar, and ScienceDirect until April 2018. The studied that were published in Iran, peer-reviewed, and designed as a randomized control trial on type I diabetes were retrieved and screened.Result: The initial search results of the electronic databases yielded 822 relevant articles. After two stages of screening, checking the references, and removing the duplicate articles in various databases, 18 articles were finally selected for the review.Conclusion: According to the results, medicinal plants have a positive impact on the performance of pancreatic beta cells in animal models through various mechanisms, such as increasing the number, size, regeneration, and reduction of the inflammation of beta cells.