Original article
Medical and Surgical Complications in Three Tertiary Hospitals in the Northeast of Iran: A Multicenter Study

Masoumeh Sarbaz; Khalil Kimiafar; Majid Khadem-Rezaiyan; Mohammad Javad Ghasri; Mohammad Reza Farhang Far; Yones Bondar Sahebi; Alireza Omranzadeh

Volume 6, Issue 2 , June 2019, Pages 40-44


  Introduction: An adverse event (AE) is defined as an intended condition caused by medical errors or during hospitalization. Evidence in this regard is scarce and outdated. The present study aimed to evaluate the prevalence of medical and surgical AEs in three tertiary hospitals in the northeast of Iran.Methods: ...  Read More

Original article
Effects of Pre-treatment with Ketamine and Tourniquet Application on the Prevention of the Pain Induced by Propofol Injection: A Randomized Controlled Clinical Trial

Mohsen Sabermoghaddam Ranjbar; Mojtaba Khezri; Majid Rajabian

Volume 6, Issue 2 , June 2019, Pages 45-48


  Introduction: The pain induced by propofol injection is a common adverse complications caused by propofol, which is ranked seventh among the 33 clinical symptoms of anesthesia. The present study aimed to investigate the effects of pre-treatment with ketamine and tourniquet inflation on the pain induced ...  Read More

Original article
Comparison of the Conventional and New Techniques of Laryngeal Mask Airway Insertion in Postoperative Sore Throat

Mohammad Gharavi Fard; Mohsen Akhondi

Volume 6, Issue 2 , June 2019, Pages 49-54


  Introduction: The present study aimed to compare the conventional and new techniques of laryngeal mask airway (LMA) insertion in terms of the rate and severity of postoperative sore throat.Methods: This clinical trial was conducted on 80 patients referring to Khatam-ol Anbia Hospitalin Mashhad, Iran ...  Read More

Effects of Statins on Gut Microbiota (Microbiome)

Milad Ashrafizadeh; Zahra Ahmadi

Volume 6, Issue 2 , June 2019, Pages 55-59


  Statins are the inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A, which are extensively used to decrease the concentration of cholesterol in patients with hyperlipidemia. Statins are divided into two categories based on their own unique properties. Considering the pleiotropic effects of statins, they ...  Read More

The Relevance of HTLV-1-associated Myelopathy/Tropical Spastic Paraparesis in Iran: A Review Study

Masoud Keikha; mohsen Karbalaei Zadeh Babaki; Luiz Augusto Marcondes Fonseca; Jorge Casseb

Volume 6, Issue 2 , June 2019, Pages 60-65


  Human T-cell lymphotropic virus type I (HTLV-I) is a retrovirus, which is the causative agent of adult T-cell leukaemia (ATL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Evidence suggests that the interaction of HTLV-1 with the cellular-immune system plays a key role in the ...  Read More

The Targeting of Autophagy and Endoplasmic Reticulum Stress Mechanisms by Honokiol Therapy

Zahra Ahmadi; Sahar Roomiani; Niloofar Bemani; Milad Ashrafizadeh

Volume 6, Issue 2 , June 2019, Pages 66-73


  In recent decades, special attention has been paid to cell death mechanisms, with the exception of apoptosis. This could be due to the resistance of cells, particularly cancer cells, to apoptosis. Among novel pathways, autophagy and endoplasmic reticulum (ER) stress have attracted the attention of researchers. ...  Read More

Case report
Acinetobacter spp. Coinfection with Elizabethkingia meningoseptica: A Case Report at a Referral Hospital in Iran

Kobra Salimiyan Rizi; Hadi Farsiani; Saeid Amel Jamehdar; Mahboubeh Mohammadzadeh

Volume 6, Issue 2 , June 2019, Pages 74-76


  Elizabethkingia meningoseptica is an emerging nosocomial gram-negative, rod-shaped pathogen in patients with underlying diseases. This bacterium is also considered to be a major pathogen in hospitalized patients. Some of the main risk factors for E. meningosepticum infections include immunosuppression ...  Read More

Case series
Various Phenotypic Expressions of the Bicuspid Aortic Valve

Tim Paterick

Volume 6, Issue 2 , June 2019, Pages 77-83


  The phenotypic expressions of the bicuspid aortic valve (BAV) are unpredictable and difficult to compartmentalize. In the modern era, BAV has been reported to account for approximately 50% of the cases with severe aortic stenosis requiring surgery and has also been associated with aortic regurgitation, ...  Read More