Zahra khorasanchi; Mohammad Vahedifard; Kimia Mohammadhasani; Yasamin Sharifan; Zahra Dehnavi; Ramtin Naderian; Ali Jafarzadeh Esfehani; Payam Sharifan; Reza Zare-Feyzabadi; Gordon A. Ferns; Majid Ghayour
Abstract
Introduction: The pandemic of COVID-19 created a psychological response. So, the psychological function of COVID-19 patients is an important subject that forces us to follow up with them.Aim: Assess the correlation between vitamin D serum concentrations and psychological functions such as insomnia, stress, ...
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Introduction: The pandemic of COVID-19 created a psychological response. So, the psychological function of COVID-19 patients is an important subject that forces us to follow up with them.Aim: Assess the correlation between vitamin D serum concentrations and psychological functions such as insomnia, stress, and depression through the COVID-19 pandemicMethods: In this cross-sectional study, blood samples from 120 COVID-19 patients (61 males and 59 females) who had more than 30 years, were taken. Also, 25(OH)D Serum level of COVID-19 patients was analyzed. The Insomnia Severity Index (ISI), Depression anxiety stress scales (DASS), and the Short Form Health Survey (SF-36) were used to analyze insomnia, anxiety, stress, quality of life, and depression.Results: The relationship between temperature (p=0.039), PCO2 (p=0.022), and serum vitamin D level was significant. Additionally, there was a significant correlation between stress (p=-0.023, OR=0.389, 95% CI for OR=0.047, 0.843), depression (p=0.012, OR=0.659, 95% CI for OR=0.476, 0.913), and the concentration of serum vitamin D.Conclusion:This study recommends that vitamin D supplementation improve psychological state in COVID-19 patients.
Payam Sharifan; Mahdi Rafiee; Niloofar Shabani; Sara Saffar Soflaei; Susan Darroudi; Mahnaz Amini; Maryam Mohamadi Bajgiran; Zahra Ghazizadeh; shima Dehghani; zahra Aghaee; Mahshid Farsi; Melika Malek; Niloofar Safari; Hamideh Ghazizadeh; Reza Assaran Darban; Mahsa Rastegar Moghaddam Poorbagher; Gordon A. Ferns; Habibollah Esmaily; Majid Ghayour
Abstract
Introduction: Depression, anxiety, and stress have been shown to be associated with quality of life and sleep quality. This association did not examine separately in men and women. In the present study, we aim to examine the association between depression, anxiety and stress with RLS, Epworth, insomnia, ...
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Introduction: Depression, anxiety, and stress have been shown to be associated with quality of life and sleep quality. This association did not examine separately in men and women. In the present study, we aim to examine the association between depression, anxiety and stress with RLS, Epworth, insomnia, apnea, PSIQ and QoL by gender in Mashhad-study data.Methods: A total of 289 individuals (143 male and 146 female) aged 30-50 years old who completed the SUVINA study. They completed the Epworth sleepiness scale (ESS), Pittsburg sleep quality index (PSQI) and quality of life (QoL). For statistical analysis, SPSS software was used for data analysis and p value 0<0.05 was considered significant.Results: Depression scores were correlated with higher scores for RLS, ESS, insomnia, and PSQI in men but inversely related to QoL (P < 0.05). RLS and PSQI was positively correlated with anxiety in women, and subjects without anxiety had lower mean of RLS and PSQI scores than the other anxiety groups (P < 0.05 for both). QoL was conversely associated with anxiety in women. Stress was related with higher scores of RLS, ESS, insomnia and PSQI in men (all P <0.05).Conclusion: OlderAlthough scores for depression, anxiety and stress were higher in women compared to men, the association of depression, anxiety and stress with RLS, quality of life and sleep quality varies between genders and unlike our expectation these disorders were more highly correlated with RLS, QoL and sleep quality in men.
Susan Darroudi; Payam Sharifan; Mahsa Rastegar Moghaddam Poorbagher; Maryam Mohamadi Bajgiran; Sara Saffar Soflaei; Hamideh Ghazizadeh; habibollah esmaily; Niloofar Shabani; Ramin Sadeghi; Vahid Reza Dabbagh Kakhki; Ali Ebrahimi Dabbagh; Mohammad Amin Mohammadi; Mohammad Amin Mohammadi; sara Moazedi; Mahdi Rafiee; reza Assaran Darban; Gordon A. Ferns; Mohsen Mohebati; majid Ghayour
Abstract
Introduction: Metabolic syndrome (MetS) is comprised of a clustering of various cardiovascular risk factors that can also affect bone health. We aimed the associations between MetS and bone mineral density (BMD) and trabecular bone score (TBS) in subjects with abdominal adiposity.Methods: Individuals ...
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Introduction: Metabolic syndrome (MetS) is comprised of a clustering of various cardiovascular risk factors that can also affect bone health. We aimed the associations between MetS and bone mineral density (BMD) and trabecular bone score (TBS) in subjects with abdominal adiposity.Methods: Individuals with body mass index less than 25 kg/m2 were enrolled from the SUVINA study and allocated into two groups according criteria of IDF for metabolic syndrome. TBS T-score and Z/T score of fore skeletal region were measured using dual-energy X-ray absorptiometry (DXA). SPSS software was used for statistical analysis and p value 0<0.05 was considered significant.Results: DXA measurements were made in 201 participants, of whom 75 had MetS and 126 did not. Scores related to the neck of femur and total femur, radius Z-score and TBST-score were lower in subjects with MetS (all P<0.05). Subjects with FBG≥100 had lower TBST-score (p < 0.05). SBP≥130 and DBP≥85 in subjects, led to the lower TBST-score, and lumbar T-score (both P < 0.05). Subjects with (LDL-C≥160 mg/dl) had lower TBST-score, neck of femur Z score, and total femur T/Z scores (all P < 0.05). TBST-score and scores related to neck of femur, and total femur were lower in participants with serum cholesterol≥200 mg/dl (P < 0.05).Conclusion: MetS is negatively associated with TBS and BMD scores. Higher levels of LDL-C and cholesterol were the most associated factors related to TBST-score decrease. The neck of femur was the most vulnerable skeletal against the MetS components increment.
Maryam Emadzadeh; Seyed Mostafa Parizadeh; Reza Jafarzadeh-Esfehani; Reza Sahebi; Ramin Sadeghi; Gordon A. Ferns; Majid Ghayour-Mobarhan
Abstract
Objectives: Various fortification strategies have been proposed to account to treat or prevent vitamin D deficiency. However, the optimum fortification approach, and the effect of these on health is not widely understood. There have been controversial reports regarding the effect of vitamin D fortification ...
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Objectives: Various fortification strategies have been proposed to account to treat or prevent vitamin D deficiency. However, the optimum fortification approach, and the effect of these on health is not widely understood. There have been controversial reports regarding the effect of vitamin D fortification on the lipid profile. The aim of present review is the evaluation of administration of vitamin D fortified products on lipid profile.Methods: We used databases including PubMed/Medline, ISI Web of Knowledge, Science Direct, Scopus and Cochrane Library. A search was conducted until 2020 Randomized controlled trials that have assessed the relationship between consumption of vitamin D fortified products and serum lipid profile were included. The relationship between fortification dose, dairy or non-dairy fortification as well as duration of intervention and plasma lipid profiles evaluated in separate sub-groups.Results: Among serum lipids including total cholesterol(TC), triglyceride(TG), low density lipoprotein(LDL) and high density lipoprotein(HDL), fortification of vitamin D was reported to have a significant effect on reducing total cholesterol (pooled estimate: -0.089 mmol/L, 95%CI: -0.134 to -0.044, p<0.001). Its effect on other lipid profiles were not significant (LDL pooled estimate:-0.115 mmol/L, 95%CI:-0.238 to 0.008; HDL pooled estimate:0.024 mmol/L, 95%CI:-0.024 to 0.071; TG pooled estimate:-0.176mmol/L, 95%CI:-0.499 to 0.148).Conclusion: This meta-analysis demonstrated that vitamin D fortification could significantly reduce TC both in long and short term interventions and in different products. However this reduction, whilst statistically significant, may not be clinically important. The effect of fortification on other lipid profile components vary depending on dose and duration.
Saeedeh Talebi; Payam Sharifan; Andisheh Norouzian Ostad; Seyedeh-Elaheh Shariati; AmirAli Moodi Ghalibaf; Mehdi Barati; Malihe Aghasizadeh; Sahar ghoflchi; Hamideh Ghazizadeh; Niloofar Shabani; Gordon A. Ferns; Hamid Reza Rahimi; majid Ghayour
Abstract
Introduction: Chamomile (Matricaria chamomilla L.), as widely used as a medicinal herb and is brewed beverages, and has been used for the treatment of several conditions. The evidence from in vitro, in vivo, and clinical studies suggests that chamomile and its many flavonoid components have anti-oxidant ...
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Introduction: Chamomile (Matricaria chamomilla L.), as widely used as a medicinal herb and is brewed beverages, and has been used for the treatment of several conditions. The evidence from in vitro, in vivo, and clinical studies suggests that chamomile and its many flavonoid components have anti-oxidant and anti-inflammatory properties. This review aimed to provide an overview of the chemical constituents of chamomile and the effectiveness of the chamomile preparations and several of its constituents for the treatment of several medical conditions. Methods: The present comprehensive review study was conducted by searching electronic databases including Scopus, Web of Sciences, Embase, and PubMed, using relevant keywords. Results: Both animal and human studies indicate the positive effects of chamomile on the antioxidant enzyme activity. However, the mechanisms involved in the action of chamomile against the production of ROS remain still unknown. When it comes to its anti-inflammatory properties, a number of in vitro, in vivo, and clinical investigations have been reported regarding to the selective inhibition of COX-2, suppression of NO production, prevention of IL-1β, IL-6 and TNFα-induced NO levels, reduction of iNOS mRNA and protein expression, impediment of leukocyte adhesion and adhesion protein up-regulation in human endothelial cells, and blockage of IL-1 α-induced prostaglandin production, TNF-α-induced IL-6 and IL-8 release. Conclusions: Current studies suggest that chamomile and its flavonoid components have anti-oxidant and anti-inflammatory properties. On the basis of the existing evidences, chamomile appears to ameliorate several diseases caused by oxidative stress as well as inflammatory reactions.
Afsaneh Bahrami; Elahe Allahyari; Afrooz Arzehgar; Mehdi Sohrabi; Elham Amirzadeh; Soheila Alipour; Gordon A. Ferns; majid Ghayour
Abstract
Introduction: The serum 25(OH)D response to vitamin D supplementation, differs between individuals. The goal of this study was the evaluation of the relationship between socioeconomic and demographic factors with the hugeness of response to vitamin supplementation, defined by statistical ...
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Introduction: The serum 25(OH)D response to vitamin D supplementation, differs between individuals. The goal of this study was the evaluation of the relationship between socioeconomic and demographic factors with the hugeness of response to vitamin supplementation, defined by statistical analysis artificial neural network (ANNs).
Methods: The prospective interventional study was conducted on 529 participants aged 19-12 years old. All participants were administrated to receive nine vitamin D capsules (50000IU vitamin D) over nine weeks. The response variables were the following: the differences between the concentrations of vitamin D before and after intervention.
Results: Among various sociodemographic factors which affect the increase in serum vitamin D amounts in response to supplementations, baseline serum vitamin D (%28.1), BMI (%13.8), physical activity (%12.1), age (%7.6), mother›s education (%6.4), and father›s occupation (%5.8) be important variables.
Conclusion: This interventional study provides specific sociodemographicrecommendations to achieve 25(OH)D targets in cases with severe vitamin D deficiency, perhaps indicating that a higher dose is require to obtain optimal Vit D levels in some individuals.
Mina Nosrati; Neda Shakour; Toktam Sahranavard; Fatemeh Sadabadi; Sara Saffar Soflaei; Hamideh Ghazizadeh; Maryam Mohammadi Bajgiran; Mohamad Reza Latifi; Mohammad Amin Mansouri; Mahmoud Ebrahimi; Mohsen Mouhebati; Seyed Hassan Mirshafee; Masoumeh Haghighi; Reza Assaran Darban; Ensieh Akbarpour; Gordon A. Ferns; Habibollah Esmaily; Majid Ghayour-Mobarhan
Abstract
Introduction: Diabetes (DM) is a type of metabolic disorder that its types are generated by collectingof genetic and environmental risk agents. Here, the association between HSPB1 polymorphism as a genetic risk factor and DM was investigated.
Methods: Total 690 participants from MASHAD cohort study ...
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Introduction: Diabetes (DM) is a type of metabolic disorder that its types are generated by collectingof genetic and environmental risk agents. Here, the association between HSPB1 polymorphism as a genetic risk factor and DM was investigated.
Methods: Total 690 participants from MASHAD cohort study population were recruited into the study.Anti-HSP27-level was assessed followed by genotyping using Taqman®-probes-based assay. Anthropometric, demographic and hematological/biochemical characteristics were evaluated. Kaplan-Meier curves were utilized, while logistic regression models were used to assess the association of the genetic variant with clinical characteristics of population.
Results: Finds was shown there are meaningful differences among groups of age, height, waist circumference, systolic blood pressure, FBG,TG, HDL-C, and hs-CRP, and was no big -significant difference between theexists in different HSP27 SNP in the two studied groups (with and without DM), also was no remarkable relation between genetic forms of HSPB1and T2DM. This investigation was the first research that analyzed the relationship between the genetic type of the HSPB1 gene (rs2868371) and Type 2 diabetes (DM2). In our population, the CC genotype (68.1%) had a higher prevalence versus GC (26.6%) and GG (5.3%) genotypes and the data shown that no genetic difference of HSPB1 gene polymorphism (rs2868371) was related with DM2.
Conclusion: HSPB1 polymorphism, rs2868371, was not associated with type 2 diabetes mellitus.
Vahideh Banazadeh; Ali Jangjoo; Andisheh Norouzian Ostad; Golnaz Ranjbar; Mahdi Jabbari Noghabi; Daryoush Hamidi Alamdari; Majid Ghayour Mobarhan; Reyhaneh Faridnia; Mohsen Nematy
Abstract
Introduction:Gastric bypass surgery is an intervention used to treat class III obesity and its complications. Evidence is scarce regarding its benefits among the Iranian population, especially its role in resolving obesity-related complaints and comorbidities. The present study aimed to investigate the ...
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Introduction:Gastric bypass surgery is an intervention used to treat class III obesity and its complications. Evidence is scarce regarding its benefits among the Iranian population, especially its role in resolving obesity-related complaints and comorbidities. The present study aimed to investigate the impact of gastric bypass surgery on the improvement of obesity-related complaints and comorbidities in morbid obesity. Methods:This study was conducted on 35 morbidly obese patients who volunteered to undergo gastric bypass surgery. Anthropometric data, comorbidity status, and dietary habits were collected at baseline and six months postoperatively. Data analysis was performed in SPSS version 16.0. Results: The majority of the patients were female (80%). A significant difference was observed in the frequency distribution of normal dietary habits (five regular meals per day) before and after surgery (P = 0.01). In comparison, the distribution was not significant for snacking and three large meals per day (P > 0.05). All complaints of eating disorders according to self-reports (e.g., overeating and night eating syndrome) significantly improved (P < 0.05 ). Moreover, the dose of the medications prescribed for the comorbidities associated with obesity reduced significantly (P = 0.001). The frequency of several obesity-related complaints (e.g., knee pain, hirsutism, acanthosis nigricans, and sleep apnea) also decreased significantly (P < 0.05). However, no significant improvement was observed in hair loss, brittle nails, and menstrual dysfunction (P > 0.05). Conclusion: Accordingly, gastric bypass surgery could improve obesity-related complaints six months postoperatively. Also, according to the patients’ self -declaration, patients’ adherence to “normal eating habits” increased during this period, and their eating disorders like night eating syndrome (NES) and overeating behaviors decreased compared to before the surgery.